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Methadone, sold under the brand name Dolophine among others, is an opioid used for opioid maintenance therapy in opioid dependence and for chronic pain management. Detoxification using methadone can be accomplished in less than a month, or it may be done gradually over as long as six months. While a single dose has a rapid effect, maximum effect can take up to five days of use. The pain-relieving effects last about six hours after a single dose. After long-term use, in people with normal liver function, effects last 8 to 36 hours. Methadone is usually taken by mouth and rarely by injection into a muscle or vein.

What Does It Do?

Methadone changes the way your brain and nervous system respond to pain so that you feel relief. Its effects are slower than those of other strong painkillers like morphine. It blocks the high you get from drugs like codeine, heroin, hydrocodone, morphine, and oxycodone.

It can also help if you’re in treatment for addiction to other opioids. It can give a similar feeling and prevent withdrawal symptoms. You may hear this called replacement therapy. Methadone replaces the opioids in your system with milder effects.

Uses and Side Effects

While there’s no set amount of time you’ll take methadone to treat an addiction, experts say it should be at least a year, and maybe more than that. The doctor will carefully track your body’s response to it and adjust your treatment. When it’s time to stop taking it, he’ll help you stop slowly to prevent withdrawal.

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With short-term use, you may notice:

• Restlessness
• Nausea or vomiting
• Slow breathing
• Itchy skin
• Heavy sweating
• Constipation
• Sexual problems

Some side effects are more serious. Call the doctor if you:

• Have trouble breathing or can only take shallow breaths
• Feel lightheaded or faint
• Get hives or a rash
• Have swollen lips, tongue, throat, or face
• Have chest pain or a rapid heartbeat
• Have hallucinations or feel confused